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- W2357445866 abstract "Objective To evaluate the inhibitory effect of HPSE antisense oligodeoxynucleotide (ASODN) on the invasiveness of human lung cancer A-549 cell lines.Methods HPSE ASODN which was complementary with initiation codon region of HPSE mRNA was designed and synthesized.After embedded by cation lipofectin,it was transfected into A-549 cells of human lung cancer.The expression of HPSE protein and HPSE mRNA in A-549 cell lines were detected by flow cytometry and RT-PCR.Meanwhile Matrigel invasive assay was used to measure the inhibitory effect of HPSE ASODN on the invasiveness of human A-549 cell lines.Results The HPSE protein and HPSE mRNA expression and invasiveness of human A-549 cells treated with ASODN of different concentrations were significantly decreased as the ASODN concentration increasing.There was a significant difference between control group and each group of ASODN respectively(P0.01),between lipofectin group and each group of ASODN respectively(P0.01),and among the groups of ASODN (P0.01).Besides,the difference of inhibitory effect was significant among the cells treated with different ASODN concentrations (P0.01).The inhibition rates of A-549 cell invasiveness were 55.6%,82.3 % and 91.2% treated by ASODN at final concentration of 100,200 and 400 nmol/L respectively.Conclusions By down-regulating the expression of HPSE mRNA and HPSE protein,HPSE ASODN has significant inhibitory effect on the invasiveness of human A-549 cell line in a dose-dependent manner." @default.
- W2357445866 created "2016-06-24" @default.
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- W2357445866 date "2010-01-01" @default.
- W2357445866 modified "2023-09-25" @default.
- W2357445866 title "Inhibition of invasiveness of human lung cancer cell lines by heparanase antisense oligodeoxynucleotide" @default.
- W2357445866 hasPublicationYear "2010" @default.
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