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- W2357460388 abstract "Objective To observe the effects of Dan-shen dripping pills on the renal failure of type 2 diabetic rats and to primarily study its mechanism. Methods The rats of type 2 diabetic model group were fore-administrated with high-carbohydrate-fat diet and then injected with 2%streptozotocin(30 mg/kg)for once. Dan-shen dripping pills solution were administered orally 500 mg/kg·d for 8 weeks to the treated group. 24h urinary albumin excretion,fasting blood glucose,fasting insulin,HOMA-insulin resistance,total cholesterol,triglyceride,low density lipoprotein cholesterol,high density lipoprotein cholesterol,serum creatinine,blood urea nitrogen,superoxide dismutase,and malondialdehyde were detected. The pathological changes of the kidneys by PASM staining were observed and the expressions of HIF-1α and VEGF in renal tissue were detected by Western blot. Results Compared with DM group,the rats of DSP group showed a significant decrease in 24Ualb,FBG,FINS,HOMA-IR,TC,TG,LDL-C,Scr,Bun and MDA(P0.01),SOD was increased(P0.01). There were no difference of HDL-C between DM and DSP group(P0.05). The expressions of HIF-1α and VEGF in renal tissue were markedly increased in DM group versus NC group(P0.01),and there was a significant decrease in expressions of HIF-1α and VEGF in DSP group versus DM group(P0.01). Conclusions The results suggested the Dan-shen dripping pills have effects on renal failure in type 2 diabetic rates, and its mechanism may be related to regulating HIF-1α/VEGF hypoxia response pathway,anti-oxidation,preventing and remeding injuries in renal cells." @default.
- W2357460388 created "2016-06-24" @default.
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- W2357460388 date "2011-01-01" @default.
- W2357460388 modified "2023-09-23" @default.
- W2357460388 title "The effects of Dan-shen dripping pills on the expressions of HIF-1α and VEGF in renal tissues of type 2 diabetic rats" @default.
- W2357460388 hasPublicationYear "2011" @default.
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