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- W2357469386 abstract "Objective To explore the changes of immune function in children with mycoplasma penumoniae pneumonia combined with kidney impairment(MPPKI).Methods The T-lymphocyte subsets of 128 cases of MPPKI were detected by alkaline phosphatase anti alkaline phosphatase method with monoclnal antibodies from 6 hospitals in our city during the past 3 years,and the serum MPAb-IgM levels of these cases were detected by dot immunogold filtration assay.The serum IgA,IgG and IgM levels of these cases were determined by comparing scattered turbidity method,the complement C3 levels of these cases were detected by immunoturbidimetry,and compared with the healthy control group.Results 1.Of 128 cases of MPPKI patients,82 patients with acute nephritis(64.06%),10 patients with nephritis compared with non-renal symptom(7.81%),24 patients with only hematuria and low level of complement C3(18.75%),and 12 patients with nephritic syndrome(9.38%).2.The CD3+ cells of patients with MPPKI was[(66.65±6.46)%],which showed no significant difference compared with that of healthy control group[(65.78±12.34)%](P0.05);while the patients did show decreased CD4+ cells[(36.46±6.68)%],that showed significant difference compared with that of healthy control group[(39.25±5.64)%](P0.01);and increased CD8+ cells[(29.12±3.42)%] compared with that of healthy control group[(25.78±4.35)%] as well as decreased CD4+/CD8+ ratio[(1.06±0.38)%] compared with that of healthy control group[(1.86±0.46)%],the difference was significant (P0.01).3.Among the patients with MPPKI,the levels of serum IgG[(16.66±3.42) g/L] and IgM[(3.96±0.66) g/L]were obviously higher than those of healthy control group[(14.48±2.54) g/L,(2.24±0.56) g/L],the differences were significant (Pa0.01).There was no significant difference in the levels of serum IgA[(3.06±0.46) g/L] between the group of patients and the healthy control group[(2.95±0.55) g/L] (P0.05),and the complement C3 level[(506±166) mg/L] was significantly lower than that of healthy control group[(529±182) mg/L](P0.01).Conclusions There are humoral and cellular immune function disorders in MPPKI children." @default.
- W2357469386 created "2016-06-24" @default.
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- W2357469386 date "2008-01-01" @default.
- W2357469386 modified "2023-09-25" @default.
- W2357469386 title "Changes of Immune Function in Children with Mycoplasma Pneumoniae Pneumonia Combined with Kidney Impairment" @default.
- W2357469386 hasPublicationYear "2008" @default.
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