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- W2357470440 abstract "Objective To explore the inhibitory effect of L-arginine on cardiac allograft vasculopathy (CAV) and its possible mechanisms.Methods The rat cardiac allograft model was used. In the control group (n=26), L-arginine was not administered after heterotopic cardiac transplantation, and the other 21 rats (experimental group) received administration of L-arginine ( 800?mg/kg every day, in drinking water) after heart transplantation. CAV score was evaluated and plasma nitric oxide (NO) was measured at 2 and 3 months after transplantation. Results Graft survival rate 2 months after transplantation was significantly (P 0.05) higher in experimental group (19 of 21, 90.5?%) than that in control group (16 of 26, 61.5?%). The plasma NO level was significantly higher in experimental group than in control group both at 2nd month ( 105.37± 10.66?)μmol/L vs ( 68.54± 6.83?)μmol/L, (P 0.05) and 3rd month ( 104.53± 12.31)?μmol/L vs ( 66.32± 10.54?)μmol/L, (P 0.05) after transplantation. CAV score was significantly higher in control group than in experimental group both at 2nd month 2.4± 0.7?vs 1.1± 0.6, (P 0.05) and 3rd month 3.0± 0.8?vs 1.6± 0.9, (P 0.05) after transplantation. The cardiac allografts in experimental group showed minimal intimal proliferation, the endothelium and internal elastic lamina remained almost intact, and reduced smooth muscle cell proliferation.Conclusions Dietary L-arginine attenuated CAV. The protective effect may be related to the generation of NO to maintain endothelial function and direct inhibit smooth muscle cell proliferation." @default.
- W2357470440 created "2016-06-24" @default.
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- W2357470440 date "2003-01-01" @default.
- W2357470440 modified "2023-09-26" @default.
- W2357470440 title "Inhibitory effect of L-arginine on cardiac allograft vasculopathy in a rat cardiac allograft model" @default.
- W2357470440 hasPublicationYear "2003" @default.
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