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- W2357475054 abstract "Objective:To observe the effect of Qishenhuoxue Granule on the sepsis rats, and the effects on the adhesion molecules and serum endotoxin.Methods:We first observed the survival time and survival rate. Rats were randomly divided into 4 groups, Group (M) with CLP; Group (T) with CLP+ the traditional Chinese medicine treated; Group (P) with CLP+ the traditional Chinese medicine pretreated;Group (S) with Sham operated. Rats were monitored in 15 days. Survival datas were compared using logrank test. At the second stage we detected the inflammatory and coagulative factors. Rats were randomly divided into 5 groups:all groups were made samely as above, and Group (N) (Normal) with no surgery and no treatment. Rats were sarcrificed at 3h, 6h, 12h, 24h and 72h, the blood and organs were harvested to be detected CD11b presenting on the surface of neutrophilic leukocyte and serum endotoxin, and ICAM-1 in lung tissue.Results:The motality rates Group T and Group P were significantly lower than Group M. The the CD11b expressing on the surface of neutrophil, ICAM-1 in lung tissues and the serum endotoxin of Group T and Group P were significantly lower than Group M.Conclusion:The Qishenhuoxue Granule can significantly decrease the mortality rate of sepsis rats,and it also can decrease the increasing of CD11b, ICAM-1 and the serum endotoxin at the early stage of sepsis, and have protective effects on sepsis rats." @default.
- W2357475054 created "2016-06-24" @default.
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- W2357475054 date "2007-01-01" @default.
- W2357475054 modified "2023-09-23" @default.
- W2357475054 title "Study of the Effect of Qishenhuoxue Granule on the Sepsis Rats" @default.
- W2357475054 hasPublicationYear "2007" @default.
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