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- W2357481215 abstract "Objective To study the modulation of heat shock protein 70(HSP70) expression by ethyl pyruvate(EP) in the hepatocyte of septic mice. Methods Cecal ligation-perforation (CLP) models were made in mice as septic model. Total of 60 mice were divided into three groups: sham group, CLP+REPS group and CLP+RLS group. Ringer's ethyl pyruvate solution (REPS) and Ringer's lactic solution (RLS) were used in two groups to resuscitate the septic mice respectively. Malonaldehyde(MDA) in hepatic tissue and hepatocyte HSP70 expression was detected in different groups. Results Malondialdehyde level in septic groups was higher than in sham group( P 0.01). EP promoted the anti-oxidative ability of hepatic tissue in septic mice. Malondialdehyde level was lower in REPS group than in RLS group[(48.18±5.98) μmol·g-1protein vs (78.34±11.16) μmol·g-1protein, P0.01]. The expression of hepatocytic HSP70 in REPS group was higher than in RLS group [(28.76±5.69) vs (20.04±4.93), P0.05]. The MDA level was negative correlated with the expression of HSP70 (r=-0.733,P0.01). Conclusion Ethyl pyruvate, as its anti-oxidative ability, can increase the expression of HSP70 of hepatocyte in septic mice." @default.
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- W2357481215 date "2008-01-01" @default.
- W2357481215 modified "2023-09-23" @default.
- W2357481215 title "Modulation of hepatocyte heat shock protein 70 expression by ethyl pyruvate in septic mice" @default.
- W2357481215 hasPublicationYear "2008" @default.
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