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- W2357487218 abstract "Objective To determine the association between HLA-G 14bp insertion/deletion polymorphism and the risk of systemic lupus erythematosus(SLE) .Methods 231 SLE patients and 367 healthy controls were recruited in this study.Polymerase chain reaction(PCR) was performed to detect the genotypes of SLE patients and controls.Clinical characteristics were analyzed between different HLA-G genotypes.Results HLA-G allelic frequencies were in Hardy-Weinberg equilibrium(χ2 = 0.095,P = 0.953 for the control group and χ2 = 1.383,P = 0.501 for the SLE patients group) .There was no association between HLA-G 14bp insertion/deletion polymorphism and the risk of SLE(P 0.05) ,meanwhile this polymorphism didn’t influence SLE disease activity index either.Furthermore,no significant difference was observed in SLE patients carrying different HLA-G genotypes in regard to the symptoms and physical signs of patients.However,further analysis showed that elevated frequencies of homozygous-14bp genotype and heterozygote genotype were observed in patients with positive anti-histone antibody and anti-U1-snRNP antibody respectively.Conclusion Our results do not support the HLA-G 14-bp insertion/deletion polymorphism as a genetic factor influencing SLE susceptibility,but the homozygous-14bp genotype(-14/-14bp) and heterozygote genotype(+14/-14bp) may have a positive effect on production of antibodies." @default.
- W2357487218 created "2016-06-24" @default.
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- W2357487218 date "2009-01-01" @default.
- W2357487218 modified "2023-09-26" @default.
- W2357487218 title "Association of HLA-G 14bp Insertion/deletion Polymorphism with Systemic Lupus Erythematosus" @default.
- W2357487218 hasPublicationYear "2009" @default.
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