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- W2357492025 abstract "Objective To study the changes of CD4+ CD25+T cells and CD4+ CD25highT cells in patients with psoriasis,and find the possible role in the pathogenesis of psoriasis.Methods Bacillus coli suspension(3.0×108/mL) 0.2mL was added to anticoagulated whole blood cells treated by citric acid and 0.3 mL plasma,and then were incubated for 1h at 37℃.The ratio of CD4+ CD25+T cells and CD4+ CD25highT cells in peripheral blood was determined by Flow Cytometry.Results The ratio of CD4+ CD25highT cells in whole blood cells was higher in group added with Bacillus coli(psoriasis experimental group)(1.88%) compare with that of psoriasis control group(1.41%)(P﹤0.01),and the ratio of CD4+ CD25+T cells and CD4+ CD25highT cells(16.86%,1.88%) was significantly lower than that of CD4+ CD25+T cells and CD4+ CD25highT cells in Bacillus coli adding whole blood cells and plasma of healthy people(Normal experimental group)(24.26%,2.81%)(P﹤0.01);The ratio of CD4+ CD25+T cells and CD4+ CD25highT cells(15.97%,1.41%) in psoriasis control group were significantly lower than that in health control group(21.75%,2.17%)(P﹤0.01).The ratio of CD4+ CD25+T cells and CD4+ CD25highT cells healthy experimental group(24.26%,2.81%) was higher than that of healthy control group(21.75%,2.17%)(P﹤0.05).Conclusion Innate and adaptive immunity disorders by external antigens stimulation,CD4+ CD25+ T cell and CD4+ CD25highT cell expression abnormality are shown in psoriasis patients.These could be associated with the pathogenesis of systematic immunology." @default.
- W2357492025 created "2016-06-24" @default.
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- W2357492025 date "2011-01-01" @default.
- W2357492025 modified "2023-09-28" @default.
- W2357492025 title "The Variation of CD4~+ CD25~+ T Cells and CD4~+ CD25~(high) T Cells in Patients with Psoriasis in Vitro Systematic Hematogenic Immunoreaction" @default.
- W2357492025 hasPublicationYear "2011" @default.
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