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- W2357496693 abstract "Objective:To investigate the possibility of sheep joint cartilage replacement by tissue_engineered cartilage using porous bioceramics as scaffold.Methods:In the experimental group( n =12),autologous articular chondrocytes were isolated and multiplied in vitro with micro_carrier technique in rotary cell culture system(RCCS)and then implanted onto the pre_molded porous β_tricalcium phosphate(β_TCP).The cell_β_TCP complexes were implanted into sheep right humeral cartilage defect.Defects in β_TCP ( n =12) group were repaired by β_TCP only,while defects in the control group( n =4) were left un_repaired.Samples were taken 3 and 6 months after operation for histological,histochemical and immuno_histochemical analysis.Results:In the experimentalgroup, cartilage_like tissue formation can be seen on the surface of the implants. Microscopic analysis demonstrated significant degradation of β_TCP and new cartilage filled in extensively with rich extracellular matrix surrounding the chondrocytes 3 months after operation. The cells were stained positively with typeⅡcollagen. Six months later, the bioceramics had almost completely degraded and abundant cartilage formation could be seen in the whole defects. In the β_TCP group, marginal cartilage ingrowth could be seen 3 months post_operationand the number of chondrocytes increased significantly after 6 months. However, no cartilage could be detected in the middle of the material. In the control group, only a small quantity of new cartilage formation could be seen along the margin of defects.Conclusions:Porous β_TCP is an ideal scaffold for cartilage tissue engineering and β_TCP_based cartilage tissue engineering is of potential clinical application." @default.
- W2357496693 created "2016-06-24" @default.
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- W2357496693 date "2002-01-01" @default.
- W2357496693 modified "2023-09-23" @default.
- W2357496693 title "Repair of sheep articular cartilage defects by tissue engineered cartilage:an experimental study" @default.
- W2357496693 hasPublicationYear "2002" @default.
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