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- W2357509104 abstract "Chemokine receptor CCR5 is a major coreceptor for HIV-1entry into cell and CCR5 antagonists can be used as a targeting preparation in the prevention of human HIV-1infection.At present,the peptide of small molecule compounds CCR5 antagonists research occupy the leading position.4-bromo-2-(bromomethyl)-1-((4-chlorobenzyl)oxy)benzene(intermediate 3)was synthesized from 1-chloro-4-(chloromethyl)benzene and 5-bromo-2-hydroxybenzaldehyde by elimination reaction,reduction reaction and bromination.N-allyl-N-(piperidin-4-yl)benzamide was prepared from 1-benzylpiperidin-4-one.Further reaction of intermediate 3with intermediate 7gave a novel non-peptide CCR5 antagonist N-allyl-N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)piperidin-4-yl)benzamide.The product has a certain biological activity.The compounds were characterized by 1 H NMR,13 C NMR,IR and MS." @default.
- W2357509104 created "2016-06-24" @default.
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- W2357509104 date "2014-01-01" @default.
- W2357509104 modified "2023-09-26" @default.
- W2357509104 title "Synthesis and Structure Characterization of N-allyl-N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)piperidin-4-yl)benzamide" @default.
- W2357509104 hasPublicationYear "2014" @default.
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