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- W2357517577 abstract "AIM:To investigate the feasibility of patient-controlled analgesia with sulfentanyl and propofol sedation for burn dressing changes. METHODS:Sixty patients ASAⅠ-Ⅱwho had thermal burns of 20-50 percent total body surface area and were scheduled for burn dressing changes were randomly divided into three groups with twenty patients in each group.Each patient received an initial loading dose of i.v.sulfentanyl 0.25μg/kg 5 min before the procedure,received target controlled infusion with propofol initial effect-site concentrations from 0.15μg/kg at 2 min before the procedure.Adjusting the propofol effect-site concentrations to maintain BIS decline by 15-20 percent of baseline.The patients were allocated to receive on-demand analgesia with one of the three PCA-sulfentanyl demand doses-1,3,and 5ug.The demand dose was delivered i.v.at a constant rate by a PCA pump with a 5-min lockout interval.Propofol and sulfentanyl comsumption,demands made per 10min,delivered per 10min and demand/delivery ratio were reorded,Pain intensity was assessed by the VAS score,Doctor and patents' satisfactories were asked.Incidence of postoperative nausea and vomiting,dizzy,respiratory depression and hypotension were recorded.RESULTS: Propofol comsumption in 5μg group were significantly lower than those in 1 and 3μg group(P0.01,P0.05),but higher in 1μg group than those in 3μg group(P0.05).Total sulfentanyl comsumption dosage in 5μg and 3μg group were significantly higher than those in the 1μg group(P0.01).During the dressing change procedure,mean VAS scores,demands made per 10min,delivered per 10min and demand/delivery ratio in the sulfentanyl 1μg groups were significantly higher than those in the 3 and 5μg groups(P0.01),and there are no difference between 3μg group and 5μg group (P0.05).Patients and doctors' satisfactories were signicantly higher in 3 and 5μg groups than those in 1μg group(P0.01),while no difference between 3μg group and 5μg group(P0.05).The incidence of dizzy were signicantly higher in 5μg groups than those in 1μg and 3μg group(P0.01,P0.05).CONCLUSION: The optimal PCA-sulfentanyl demand dose in our study is 3μg after an i.v.initial loading dose of 0.25μg/kg and a lockout interval of 5 minutes,Combining with propofol for sedation is safety and feasible." @default.
- W2357517577 created "2016-06-24" @default.
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- W2357517577 date "2010-01-01" @default.
- W2357517577 modified "2023-09-26" @default.
- W2357517577 title "Patient-controlled analgesia with sulfentanyl and propofol sedation for burn dressing changes" @default.
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