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- W2357529196 abstract "OBJECTIVE:To review the therapeutic efficacy and safety of Kangai injection in the adjunctive treatment of breast cancer.METHODS:According to include and exclude criterion,and searching strategy,randomized controlled trials(RCT)and quasi-randomized controlled trials(qRCT)of Kangai Injection combined with conventional chemotherapy for the treatment of brest cancer.Quality was evaluated and Meta-analysis was carried out.RESULTS:7 RCT and 1 qRCT were included,involving 697 patients in total.Meta-analysis indicated that there was no statistical significance in effective rate between treatment group and control group [RR=1.10,95%CI(0.93,1.30),P=0.29];there was statistical significance in the improvement rate of life of quality[RR= 2.18,95%CI(1.44,3.29),P0.01],the increase and stability index of body weight [RR=2.65,95%CI(1.42,4.95),P0.01] between treatment group and control group.The incidence of leucopenia and dysfunction of liver and kidney in treatment group were lower than in control group,but the incidence of grade Ⅲ-Ⅳ leucopenia and dysfunction of liver and kidney had no decreasing change in treatment group.The incidence of grade Ⅲ-Ⅳ alopecia in treatment group was lower than in control group,but treatment group couldn't reduce the probability of occurrence of alopecia.The incidence of thrombocytopenia and gastrointestinal reaction between 2 groups were similar to each other,there was no statistical significance.CONCLUSIONS:Adjunctive treatment of Kangai injection for breast cancer can improve the quality of life and the body weight,decrease parts of toxic and side-effects,but it also need high-quality large-scale long-term studies for further validation." @default.
- W2357529196 created "2016-06-24" @default.
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- W2357529196 date "2013-01-01" @default.
- W2357529196 modified "2023-09-25" @default.
- W2357529196 title "Meta-analysis of Therapeutic Efficacy and Safety of Kangai Injection in the Adjunctive Treatment of Breast Cancer" @default.
- W2357529196 hasPublicationYear "2013" @default.
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