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- W2357549334 abstract "Objective To explore the secretive activities of mice spleen cells induced by DNA recombinant of HSP70 of mycobacterium tuberculosis and HPV16 E6/E7.Methods DNA recombinants were vaccinated to mice through muscle injection,and spleen cells were isolated. Cytokines and antibodies were detected by ELISA method,and mRNAs of cytokines were detected by RT-PCR method. Results Secretions of cytokines IL-2 and IFNγ increased by injection of DNA vaccinations based on HPV16 E6/E7. The increased quantity by DNA recombinants of HSP70 of mycobacterium tuberculosis and HPV16 E6/E7 is much higher than that induced by DNA vaccinations without recombinated with HSP70. However, secretions of IL-10 and antibodies remained. Conclusion Cellular immunity in mice could be induced by DNA vaccines based on HPV16 E6/E7. It could be much stronger induced by DNA recombinants of HSP70 of mycobacterium tuberculosis and HPV16 E6/E7. However, humoral immunity remained." @default.
- W2357549334 created "2016-06-24" @default.
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- W2357549334 date "2003-01-01" @default.
- W2357549334 modified "2023-09-25" @default.
- W2357549334 title "Secretive Activities of Mice Spleen Cells Induced by DNA Recombinant of HSP70 of Mycobacterium Tuberculosis and HPV16 E6/E7" @default.
- W2357549334 hasPublicationYear "2003" @default.
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