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- W2357559968 abstract "Objective To investigate the effect of prostaglandin E 1 (PGE 1) on hepatic fibrogenesis and its mechanism in rats with schistosomiasis japonica. Methods The changes of type Ⅰ collagen, type Ⅲ collagen and transforming growth factor beta 1 (TGF-β 1) in the livers were determined by immunohistochemical streptavidin biotin-peroxidase complex method and computer multimedia pathologic picture analysis before and after rats with schistosomiasis japonica were treated by PGE 1. Results (a) Type Ⅰ collagen, type Ⅲ collagen and TGF-β 1 were mainly distributed in egg granulomas in the liver of infected rats, which showed dense coloration and became thin coloration after PGE 1 treatment. (b) Amounts of typeⅠ collagen, type Ⅲ collagen and TGF-β 1 were 0.2571±0.1939, 0.2459±0.1836 and 0.1351±0.0941 respectively in PGE 1 treated-group, which were less than those (0.4759±0.2401, 0.4612± 0.1987 and 0.3450±0.2152 respectively) of control-group(P0.05). (c) In infected rats with or without PGE 1 treatment, a positive correlation could be demonstrated by Spearman analysis between type Ⅰ collagen and TGF-β 1(r=0.9636,P0.05;r=0.8667,P 0.05 respectively); and that between type Ⅲ collagen and TGF-β 1(r=0.9636,P0.05,r=0.9272,P0.05, respectively). Conclusion PGE 1 significantly suppressed hepatic fibrogenesis in schistosomiasis japonica, whose mechanism was probably associated with suppressing of TGF-β 1 expression by PGE 1." @default.
- W2357559968 created "2016-06-24" @default.
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- W2357559968 date "2001-01-01" @default.
- W2357559968 modified "2023-09-26" @default.
- W2357559968 title "THE EFFECT OF PROSTAGLANDIN E_1 ON HEPATIC FIBROGENESIS IN RATS WITH SCHISTOSOMIASIS JAPONICA" @default.
- W2357559968 hasPublicationYear "2001" @default.
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