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- W2357566360 abstract "OBJECTIVE:To investigate the relationship between HLA-DPB1 polymorphisms and gastric cancer and the infection of Hp in population at the high and low areas of gastric carcinoma in northern China.METHODS: PCR-RFLP was applied to analysis HLA-DPB1 polymorphisms in 863 cases and ELISA was used to determine Hp-IgG.RESULTS: 1) Four HLA-DPB1 polymorphisms were detected: The most predominant DPB1 allele was DPB1*1401 with the frequency of(65%),followed by DPB1*1701(5.4%),*0901(4.0%),*0301(0.9%);2) *0901 and *1701 alleles were found significantly different in the poqulation between the high and low areas of gastric carcinoma(*0901: χ2=36.145,P0.01;1701:χ2=35.526,P0.01);3)Between the no gastric cases and gastric carcinoma,no difference among DPB1*0901,*1401 and *1701 was found;no significant difference was found among DPB1*0901,*1401,*1701 alleles between Hp+positive and Hp-negative population.CONCLUSIONS: HLA-DPB1 *0901 and *1701 have significant differences in the population between the high and low areas of gastric carcinoma,and no association was found between 0901,1401,*1701 and gastric cancer susceptibility and infection susceptibility of Hp." @default.
- W2357566360 created "2016-06-24" @default.
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- W2357566360 date "2008-01-01" @default.
- W2357566360 modified "2023-09-24" @default.
- W2357566360 title "HLA-DPB1 polymorphisms in population at high and low risk areas of gastric carcinoma" @default.
- W2357566360 hasPublicationYear "2008" @default.
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