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- W2357598856 abstract "Objective To compare the anesthetic effects of ketamine plus pentobarbital and fentanyl plus pentobarbital for open heart surgery in minipigs.Methods Thirty-six minipigs were randomly divided into ketamine(K) group and fentanyl(F) group.Eighteen minipigs in K group received ketamine 3mg/kg and pentobarbital 20mg/kg intramuscularly for induction and intubation,then were intravenously given ketamine 5mg/kg·h),pentobarbital 8-10mg/(kg·h) and pipecuronium 0.1mg/(kg·h) for maintenance.The other 18 in F group received pentobarbital 30mg/kg intramuscularly for induction and intubation,then were intravenously given fentanyl 15-20μg/(kg·h),pentobarbital 8-10/(kg·h) and pipecuronium 0.1mg/(kg·h) for maintenance.During experimental treatment,vital signs were monitored and hemodynamic parameters were recorded,the anesthetic effectiveness was assessed,and postponed extubation was observed in all minipigs of both groups.Results All the minipigs in K group survived the operation,and 2 cases in F group died.The time of anesthesia induction and ventilation assistance in group K was shorter than that in group F(P0.01 and P0.001,respectively).Heart rate,respiratory rate and mean artery pressure were more stable in the former group than in the latter(P0.05).In addition,K group had significantly higher score for anesthetic effect assessment than F group(P0.05).Conclusion Low-dose ketamine plus pentobarbital takes effects rapidly during induction,and has a slight inhibitory effect on respiratory and cardiac system without postponed extubation." @default.
- W2357598856 created "2016-06-24" @default.
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- W2357598856 date "2010-01-01" @default.
- W2357598856 modified "2023-09-24" @default.
- W2357598856 title "Comparative study of two kinds of anesthetic methods for open heart surgery in minipigs" @default.
- W2357598856 hasPublicationYear "2010" @default.
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