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- W2357611244 abstract "Objective The association of various subtype human papillovirus(HPV) infection with precancerous lesions of uterine cervix are investigated.Methods HPV typing test was performed for 524 cases with precancerous lesions of uterine cervix proven by cytological examination and histopathological examination,including 251 cases of cervicitis,130 cases of cervical intraepithelial neoplasia Ⅰ(CIN Ⅰ),67 cases of CIN Ⅱ,61 cases of CIN Ⅲ and 15 cases of infiltrating cervix cancer(ICC).Results 1.Of 524 patients,291 of them(55.53%) were found with HPV-positive,the higher grade of lesions of uterine cervix was,the more the infection rate was(P0.01).The infection rate differed significantly among various age groups(P0.01),the highest risk age was from 21 to 50 years.2.20 subtypes of HPV were isolated,16 of them was high risk type,4 of them was low risk type.The HPV subtype varied with severity of cervix diseases increased,cervicitis group presented with HPV16,58,11,31,33 and 6;low grade of uterine cervix lesion group(CIN Ⅰ) commonly presented with HPV 16,58,18,31,56,11 and 33,and high grade lesion group(CIN Ⅱ～Ⅲ) were found with high risk type HPV 16,58,18,31,33,59 and 56.7 types of high risk HPV were found in 15 cases with ICC,including types 16,58,18,31,33,59 and 68.HPV16 subtype increased significantly with higher grade of the cervix lesions(P0.01).Conclusion The highest infected HPVof high risk types 16,58,18,31 and 33 were the major pathogen,HPV16 was especially correlated with cervix disease severity,continuous high risk HPV infection and multi-infection results in cervix canceration." @default.
- W2357611244 created "2016-06-24" @default.
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- W2357611244 date "2009-01-01" @default.
- W2357611244 modified "2023-09-23" @default.
- W2357611244 title "The relation of various sub-type HPV infection with precancerous lesions of uterine cervix" @default.
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