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- W2357618063 abstract "Objective To study the effects of transplantation of fetal spinal cord and basic fibroblast growth factor on nerve regeneration in spinal cord after spinal cord injury in adult rats.Methods Thirty-six Wistar rats were divided into 3 groups: Group A,cord hemisection and fetal spinal cord grafting;Group B,cord hemisection,fetal spinal cord grafting plus bFGF;Group C,hemisection of the cord only.After 1 to 8 weeks after injury,the rats were examined by combined behavioral score(CBS)to evaluate the recovery of neurological function.The slides with Nissl staining were used to measure the size of the neurons.The positive cells were quantitatively analyzed with a computer image analysis system.The level of NF200 expression were detected by immunohistochemical method.Results The transplantation of fetal spinal cord and basic fibroblast growth factor could prevent the atrophy of neurons after spinal cord injury in adult rats.The size of neurons in group A and B were more than that of group C(P0.05).These increase in size of neurons was parallel to a significant improvement in neurological function.Conclusion The combination of the transplantation of fetal spinal cord and basic fibroblast growth factor can improve nerve regeneration of spinal cord after SCI in rats." @default.
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- W2357618063 date "2005-01-01" @default.
- W2357618063 modified "2023-09-26" @default.
- W2357618063 title "Effects of transplantation of fetal spinal cord and basic fibroblast growth factor on nerve regeneration after spinal cord injury" @default.
- W2357618063 hasPublicationYear "2005" @default.
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