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- W2357631100 abstract "Objective To study the effects of angiogenesis inhibitor TNP 470 infusion combined with transarterial chemoembolization (TACE) on the growth and metastasis of the implanted hepatic VX2 tumor in rabbits.Materials and Methods Two weeks after VX2 tumor was inoculated into the liver, the 45 Japanese white rabbits were randomly divided into three groups. (A) Control group: no treatment was given. (B) TACE group. (C) TACE plus TNP 470 infusion group: 3 days after TACE procedure TNP 470 was infused intravenously with a dose of 30 mg/kg every other day for 18 days. Five weeks after tumor inoculation, all rabbits were sacrificed and the size and necrotic area of the implanted tumor were measured. The presence of metastasis in the liver and lungs was recorded.Results Five weeks after inoculation, the mean volume and necrosis rate of the implanted tumor were 26.5±6.5cm 3 and 35.5±9.2% in group A, 19.9±7.3cm 3 and 52.4±17.8% in group B, and 14.7±4.6cm 3 and 69.5±12.6% in group C, respectively. Significant difference was seen between each group (P0.05). The incidences of metastasis in liver and lungs were 15/15 (100%) and 11/15 (73.3%) in group A, 15/15 (100%) and 10/15 (66.7%) in group B, and 7/15 (46.7%) and 5/15 (33.3%) in group C, respectively. No significant difference was found between group A and B (P 0.05), while significant difference existed between group A and C, and between group B and C (P0.05). Conclusion Although TACE can inhibit the growth of the implanted VX2 tumor, it obviously has no effect on its metastasis. TACE followed by infusion of TNP 470, an angiogenesis inhibitor, can not only inhibit the growth of the implanted tumor, but also can prevent the tumor from developing metastasis to the live and lungs." @default.
- W2357631100 created "2016-06-24" @default.
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- W2357631100 date "2002-01-01" @default.
- W2357631100 modified "2023-09-26" @default.
- W2357631100 title "Effects of TACE plus Angiogenesis Inhibitor TNP-470 Infusion on the Growth and Metastasis of the Implanted Hepatic Tumor in Rabbits" @default.
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