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- W2357658049 abstract "Objective:To establish a method of HPLC-electrospray ion trap mass spectrometry to detect granisetron in human plasma.Methods:Chromatographic column was Hypurity C18(210 mm×150 mm,5 μm);The mobile phase was 10 mmol·L-1 ammonium formate-0.1% methanoic acid-acetonitrile(20∶30∶50);The flow rate was 0.2 mL·min-1 and temperature of column was 40 ℃.A MS/MS selective reaction monitoring mode was taken to quantitate granisetron in human plasma.Results:Standard curve was linear in the range of 0.1-59.8 ng·mL-1(r=0.9973).The lower limit of detection of granisetron was 0.06 ng·mL-1.The absolute recovery was more than 70% and the relative recoveries of granisetron were in the range of 80%-120%.Relative standard deviation of intraday and interday assays of granisetron were both less than 15%.Conclusion:The method is convenient and sensitive for detecting the concentration of granisetron in plasma,it can be used to study the pharmacokinetics and bioequivalence of granisetron." @default.
- W2357658049 created "2016-06-24" @default.
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- W2357658049 date "2009-01-01" @default.
- W2357658049 modified "2023-09-26" @default.
- W2357658049 title "LC-MS determination of granisetron in human plasma" @default.
- W2357658049 hasPublicationYear "2009" @default.
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