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- W2357660368 abstract "OBJECTIVE To study the effects of oxymatrine on joint inflammation and T cell subsets in CIA rats.METHODS Rats were randomly divided into 6 groups: normal control group,collagen-induced arthritis(CIA) model group,high-dose OMT(80 mg·kg-1·d-1)group,middle-dose OMT(40 mg·kg-1·d-1)group,low-dose OMT(20 mg·kg-1·d-1) group and total glucoside tripterygium(40 mg·kg-1·d-1)group.To establish CIA model,all rats were injected with mixture of sheep type Ⅱ collagen protein and Freund's complete adjuvant(FCA) intradermally at the right hindfoot,and injected again 1 week later at multipoints of the end of tail to boost the immunization.The intragastric administration procedure was performed from the first day after boosting immunization once a day for 4 weeks.Arthritis index(AI) was recorded every week.The blood sample was taken after the last administration to analyze T cell subsets by Flow Cytometry;serum TNF-α and IL-1β contents were measured by ELISA.Synovium of joint were fixed in 4% paraformaldehyde,and the hepatic pathological changes were observed.RESULTS OMT could improve arthritis index(P0.05),decrease CD4+T level(P0.05),increase CD8+T level(P0.05),and also reduce CD4+/CD8+ ratio(P0.05).The levels of pro-inflammatory cytokines,TNF-α and IL-1β,were markedly decreased(P0.01),too.Morphological observation indicated that OMT had significant inhibitory effect on synovial cells proliferation.CONCLUSION OMT may play a therapeutic action on rheumatoid arthritis through adjusting the levels of T cells and cytokine." @default.
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- W2357660368 date "2012-01-01" @default.
- W2357660368 modified "2023-09-24" @default.
- W2357660368 title "Effects of Oxymatrine on Joint Inflammation and T Cell Subsets in Rats with Collagen Induced Arthritis" @default.
- W2357660368 hasPublicationYear "2012" @default.
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