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- W2357661657 abstract "AIM:To study the effects of genistein on JAR/MTX cell proliferation,apoptosis and invasion and it's mechanism in vitro.METHODS: MTT assay,Annexin-Ⅴ and propidium iodide label analysis and invasion assay were used to determine the effects of genistein on proliferation,apoptosis and invasiveness in JAR/MTX methotrexate-resistant human choriocarcinoma cells.RT-PCR was used to estimate the relative mRNA amounts of estrogen receptor(ER),MTA3 and snail in the cells.Western blotting and gelatin zymography assay were used to estimate the relative protein amounts of MMP-2,MMP-9 and E-cadherin in the cells.RESULTS: After treatment of genistein,the proliferation and invasiveness of JAR/MTX cells were decreased significantly in a dose-dependent manner.10 μmol/L genistein induced apoptosis,whereas 25,50,100 μmol/L genistein induced apoptosis and necrosis significantly.Genistein led to an increase in ERβ,MTA3 mRNA and E-cadherin protein expression,and decreases in the amounts for snail mRNA and MMP-2 and MMP-9 protein expression of JAR/MTX cells.CONCLUSIONS: Genistein inhibits the cell proliferation by inducing cell apoptosis and necrosis.Genistein also may inhibit JAR/MTX cell invasion in part through the upregulation of E-cadherin and downregulation of MMP-2 and MMP-9.The signal transduction pathway of invasion suppression induced by genistein in JAR/MTX cells may be as follows: MTA3→snail→ E-cadherin." @default.
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- W2357661657 date "2007-01-01" @default.
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- W2357661657 title "Effects of genistein on proliferation,apoptosis and invasiveness in methotrexate-resistant human choriocarcinoma JAR/MTX cells and it's mechanism" @default.
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