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- W2357662655 abstract "Objective To explore the clinical significance of platelet-relevant parameters in diagnosis of thrombocytopenia. Methods Platelet-relevant parameters including platelet count( PLT),mean platelet volume( MPV),platelet distribution width( PDW),ratio of platelet larger cells( P-LCR) and immature platelet fraction( IPF%) of 137 patients with thrombocytopenia [34 patients with idiopathic thrombocytopenic purpura( ITP),18 patients with aplastic anemia( AA),11 patients with myelodysplasia syndrome( MDS),36 patients with chronic hepatitis B,33 patients with liver cirrhosis,5 patients with liver transplantation]and 60 normal controls were measured by automatic blood cell analyzer Sysmex XE-5000. Then all these results were analyzed and compared with clinical data. Results Platelet count in six groups was significantly lower than that of control group( P 0. 01). IPF% in peripheral blood was obviously higher in patients with ITP,MDS,liver cirrhosis and liver transplantation in comparison with that of control group( P 0. 05). IPF% in patients with ITP and liver transplantation was significantly higher( P 0. 01). Additionally,MPV was obviously higher in patients with ITP,liver cirrhosis and liver transplantation compared with that of control group( P 0. 05). P-LCR was obviously higher in patients with ITP,chronic hepatitis B,Liver cirrhosis and liver transplantation compared with that of control group( P 0. 05),especially in patients of liver transplantation( P 0. 01). PDW in patients with ITP,chronic hepatitis B,liver cirrhosis and liver transplantation was obviously higher than that of normal control group( P 0. 05),and it in ITP and liver transplantation groups was significantly higher( P 0. 01). Furthermore,IPF% of aplastic anemia group was obviously lower than that of normal controls( P 0. 05),so did MPV,P-LCR and PDW in patients with aplastic anemia,but their difference had no statistical significance( P 0. 05). Conclusion The results of IPF%,MPV,PDW and P-LCR have certain referential value in diagnosis and clinical treatment of patients with thrombocytopenia." @default.
- W2357662655 created "2016-06-24" @default.
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- W2357662655 date "2013-01-01" @default.
- W2357662655 modified "2023-09-26" @default.
- W2357662655 title "Study on clinical significance of platelet-relevant parameters in diagnosis of thrombocytopenia" @default.
- W2357662655 hasPublicationYear "2013" @default.
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