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- W2357674769 abstract "Objective To investigate the effect of Saccharomyces Boulardii on clinical symptoms improvement and inflammatory response of diarrhea-predominant irritable bowel syndrome( IBS-D). Methods A total of 112 patients with IBS-D admitted during January 2013 and December 2014 were randomly divided into observation group( n = 56) and control group( n = 56). The control group was treated with routine treatment combined with guidance for diet and lifestyle,while the observation group was added with Saccharomyces Boulardii on the basis of control group treatment. A course of treatment was 8 weeks. The differences of IBS-D related symptoms,and levels of serum interleukin-6( IL-6),tumor necrosis factor-α( TNF-α) and nuclear factor-κB( NF-κB) before and after the treatment were observed in the two groups. Results The symptoms were obviously improved in the two groups after the treatment,and the total efficiency in the observation group was significantly higher than that in control group( P 0. 01); IBS-D related symptom scores after the treatment in the two groups were significantly lower than those before the treatment( P 0. 05),and the decreased score in the observation group was more significant than that in the control group( P 0. 05). The serum IL-6,TNF-αand NF-κB levels after treatment in the observation group were significantly lower( P 0. 05); the indexes in the control group were lower than those before the treatment,but the differences were not statistically significant( P 0. 05). The differences of serum IL-6,TNF-α and NF-κB levels after the treatment in the two groups were statistically significant( P 0. 05). Conclusion Saccharomyces boulardii can adjust abnormal inflammatory reaction of IBS-D patients by inhibiting the NF-κB activity and therefore improve the clinical symptoms." @default.
- W2357674769 created "2016-06-24" @default.
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- W2357674769 date "2015-01-01" @default.
- W2357674769 modified "2023-09-24" @default.
- W2357674769 title "Effect and Mechanisms of Saccharomyces Boulardii in Diarrhea-Predominant Irritable Bowel Syndrome" @default.
- W2357674769 hasPublicationYear "2015" @default.
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