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• W2357679849 abstract "ABSTRACT Objective:To measure the expression levels of matrix metalloproteinase 2 (MMP2) and its inhibitor, tissue inhibitor of metalloproteinase 2 (TIMP2), and to discuss their relationship with the colorectal neoplasia. Methods: RTPCR technique was used to measure the levels of MMP2 mRNA and TIMP2 mRNA in 12 cases of colon carcinoma and 20 cases of rectal carcinoma (involved 4 recurrent cases). Results: The MMP2 mRNA was expressed in 27/32 tumor tissues and 18/32 normal tissues. For the TIMP2, the rates were 29/32 and 25/32, respectively. The levels of MMP2 mRNA in tumor tissues were negatively correlated with the ages of patients. Eleven cases had the higher level of MMP2 mRNA in normal tissue than in tumor tissue, and the incidence in colon carcinoma was much higher than that in rectal carcinoma (18/32,16/32,P0.05). Conclusion: The biological behaviours of colorectal cancer changed with the ages of patients which may be correlated with the expression levels of the MMP2 in cancer tissue. The biological behaviours of the colon cancer were different from those of rectal cancer." @default.
• W2357679849 created "2016-06-24" @default.
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• W2357679849 date "1998-01-01" @default.
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• W2357679849 title "EXPRESSION OF MATRIX METALLOPROTEINASE 2 AND TISSUE INHIBITOR OF METALLOPROTEINASE 2 mRNAs IN COLORECTAL NEOPLASIA" @default.
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