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- W2357694160 abstract "Objective To describe the clinico-pathological features and explore the pathogenesis of rifampicin-associated acute renal failure (ARF).?Methods Clinico-pathological features of 3 patients with rifampicin-associated ARF were analyzed. Rifampicin-dependent antibody in the patient's serum was detected by Coomb's test.?Results The 3 patients all had a history of using the drug in the past. The clinical features of the illness were first characterized by fever and gastrointestinal symptoms after intake of rifampicin. Anuria then developed abruptly, which was accompanied by renal dysfunction, thrombocytopenia and hemolytic anemia, and sometimes also by impaired liver function. Renal biopsy revealed acute tubular necrosis. Serum rifampicin dependent antibody was positive in all of the 3 cases.?Conclusion Rifampicin can induce acute renal failure. Renal function should be closely monitored in the susceptible patients. Renal biopsy and detection of serum rifampicin-dependent antibody will help establish the diagnosis of rifampicin induced ARF." @default.
- W2357694160 created "2016-06-24" @default.
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- W2357694160 date "2002-01-01" @default.
- W2357694160 modified "2023-09-26" @default.
- W2357694160 title "Rifampicin-induced acute renal failure and its pathogenesis (report of 3 cases and literature review)" @default.
- W2357694160 hasPublicationYear "2002" @default.
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