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- W2357712334 abstract "Objective ALC-MS/MS method was established for the determination of fexofenadine hydrochloride and pseudoephedrine hydrochloride extended-release capsules were obtained in 24 healthy volunteers.Methods Phenformin was used as internal standard.A C18 column was used,with the mobile phase of acetonitrile ammonium acetate.ESI was applied and operated in positive ion selective reaction monitoring mode.The concentration of fexofenadine and pseudoephedrine in human plasma was determined by the method of LC-MS/MS with gradient elution.The pharmacokinetic profiles of oral single and multiple doses of fexofenadine hydrochloride 60mg and pseudoephedrine hydrochloride 120 mg extended-release capsules were obtained in a randomized.Results The plasma concentrations of fexofenadine hydrochloride and pseudoephedrine hydrochloride indicated that steady state was achieved on day 6 in the multiple-dose study.An extended-release effect of pseudoephedrine with the combination capsule formulations was observed in vivo.There are no difference between gender of its pharmacokinetic parameters(P 0.05).The correlation between pharmacokinetic parameters,and dose were observed in this study.Conclusion The method was sensitive,specific,simple,and suitable for drug level monitoring in clinical pharmacokinetic study" @default.
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- W2357712334 date "2012-01-01" @default.
- W2357712334 modified "2023-09-23" @default.
- W2357712334 title "The Rope Pseudo Hemp Sustained-release Capsules in China Healthy Body Pharmacokinetics" @default.
- W2357712334 hasPublicationYear "2012" @default.
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