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- W2357712500 abstract "Objective To study the role of inflammatory mediators on cerebral damage caused by severe acute pancreatitis(SAP) in rats.Methods Sixty male SD rats were equally randomized into two groups of SAP(establishing SAP model with cerebral damage by retrograde injection of 3.5% sodium taurocholate into pancreatic duct) and C(sham operated).The rats in two groups were equally divided into three subgroups of 3,6 and 12 hours.Serum TNF-α and IL-1β were detected by RIA.The TNF-α mRNA and IL-1β mRNA,the contents of malondialdehyde(MDA) and superoxide dismutase(SOD) and nuclear factor kappa B(NF-κB) p65 activity in brain tissues were measured with RT-PCR,chemical colorimetry and immunohistochemistry,respectively.Results Compared to group C,serum TNF-α and IL-1β,the contents of MDA,TNF-α mRNA,IL-1β mRNA and NF-κB p65 activity in brain tissues were all gradually increased,but SOD decreased,as the time prolonged(P0.01).ConclusionInflammatory mediators play an important role in SAP with cerebral damage in rats." @default.
- W2357712500 created "2016-06-24" @default.
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- W2357712500 date "2012-01-01" @default.
- W2357712500 modified "2023-09-28" @default.
- W2357712500 title "Role of inflammatory mediators on cerebral damage caused by severe acute pancreatitis in rats" @default.
- W2357712500 hasPublicationYear "2012" @default.
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