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- W2357715611 abstract "OBJECTIVE:To investigate the preventive and treatment effects and action mechanisms of Lycium barbarum polysaecharide(LBP)on rats with alcoholic fatty liver(AFL).METHODS:In the treatment group,the rats were intragastrically administered with ethanol for 10 wk to establish chronic AFL model,then treated with LBP for 10wk,with alcohol withdrawal group as positive control for the comparison before and after treatment;the prevention group was intragastrically administered with ethanol and LBP synchronously for 10wk,with model group as comparison.The main outcome measures were:hepatic pathologic changes,levels of ALT,AST,γ-GT,GSH-PX,SOD,GSH,MDA,expressions of CYP2E1 gene and its protein.RE- SULTS:LBP could inhibit the expression of CYP2E1 gene and its protein,reduce the activities of ALT,AST andγ-GT,increase the activities of GSH-PX and SOD,increase the content of GSH but reduce the production of MDA,and significantly improve and prevent alcoholic fatty liver pathologic changes.CONCLUSION:LBP can effectively prevent and treat AFL by reducing the lipid peroxidation." @default.
- W2357715611 created "2016-06-24" @default.
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- W2357715611 date "2007-01-01" @default.
- W2357715611 modified "2023-09-25" @default.
- W2357715611 title "Action Mechanism of Lycium Barbarum Polysaccharide in the Prevention and Treatment of Alcoholic Fatty Liver in Rats" @default.
- W2357715611 hasPublicationYear "2007" @default.
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