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- W2357718586 abstract "Objective To explore the plasma concentration measurement method and to study the pharmacokinetic profiles of Levodopa Microcapsules Intragastric Floating Tablets in Beagle dogs.Methods An HPLC method was developed to determine the content of levodopa in the blood samples from Beagle dogs.The mobile phase was consisted of water and methanol(95∶5),containing EDTA 0.08mmol·L-1,potassium dihydrogen phosphate 70mmol·L-1,and heptane sulfonate 2.08mmol·L-1.The flow rate of mobile phase was 0.5mL·min-1.The excitation wavelength of fluorescence detection was 278nm,and the emission wavelength of fluorescence detection was 325nm.Six Beagle dogs were given Levodopa Microcapsules Intragastric Floating Tablets,and the blood from the forelimb vein were collected at different time after administration.According to the result of concentration of levodopa in plasma,pharmacokinetic parameters were calculated with 3P97software.Results The linear range was 0.078-20 μg·mL-1.The minimum detection limit was 0.078μg·mL-1.The RSD of within-day was below 8.10%,and the RSD of between-days was below 13.52%.The recovery was between 105.1%-113.9%.The concentration-time curve of Levodopa Microcapsules Intragastric Floating Tablets fitted to one-compartment model.The main pharmacokinetic parameters of Levodopa Microcapsules Intragastric Floating Tablets was t1/2(1.09±0.46)h,tmax(1.32±0.54)h,Cmax(1.33±0.31)μg·mL-1,and AUC(3.31 ±1.26)μg·h·mL-1.Conclusion The method was simple and rapid,which can be used to determine the levodopaplasma concentration and study the pharmacokinetic profiles." @default.
- W2357718586 created "2016-06-24" @default.
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- W2357718586 date "2014-01-01" @default.
- W2357718586 modified "2023-09-25" @default.
- W2357718586 title "Pharmacokinetic study of Levodopa Microcapsules Intragastric Floating Tablets in Beagle dogs" @default.
- W2357718586 hasPublicationYear "2014" @default.
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