Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357757910> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2357757910 abstract "Aim To evaluate the efficacy and tolerability of pregabalin(PBG) as add-on therapy in patients with refractory partial seizures. Methods In this multicenter, double-blind, randomized, placebo-controlled trial, 225 patients diagnosed with partialonset seizures were randomly divided into a PBG therapy group and a placebo group. All patients entered a 6-week baseline period followed by an 8-week titration interval and an 8-week maintenance period. The starting dose of PBG group was 150 mg·d-1, and target dose was 400 mg·d-1. The main outcome was 28-day seizure responses ratio. The secondary outcomes points included 28-day seizure response ratio of all seizure types, 28-day seizure reduction rate, clinical seizure frequency evaluation, percentage of patients with reduction of secondary generalized tonic clonic seizures(SGTC), percentage of patients with seizure free or more than 50% seizure reduction, Clinical Global Impression(CGI) rating scales, and adverse events. Results The 28-day seizure response ratio of PBG group was(-40.24±37.88), and the placebo group was(-22.84 ± 37.61)%(F=15.063 9,P=0.000 1). The rate of adverse event of PBG and placebo group was 60.53% and 47.75% respectively without statistical significance. However, the adverse effect rate of PBG group was higher than that of placebo group(45.61% vs 23.42%, P=0.000 7). Commonly reported adverse effects were dizziness, sleepiness, blurred vision and fatigue. Conclusion Pregabalin treatment was generally well tolerated and was associated with significant reductions in seizure frequency as adjunctive treatment for partial-onset seizures." @default.
- W2357757910 created "2016-06-24" @default.
- W2357757910 creator A5007843868 @default.
- W2357757910 date "2014-01-01" @default.
- W2357757910 modified "2023-09-26" @default.
- W2357757910 title "Multicenter Randomized, Double-Blind, Placebo-controlled Trial of Pregabalin as Add-on Therapy in Patients with Refractor Partial Seizures" @default.
- W2357757910 hasPublicationYear "2014" @default.
- W2357757910 type Work @default.
- W2357757910 sameAs 2357757910 @default.
- W2357757910 citedByCount "0" @default.
- W2357757910 crossrefType "journal-article" @default.
- W2357757910 hasAuthorship W2357757910A5007843868 @default.
- W2357757910 hasConcept C126322002 @default.
- W2357757910 hasConcept C142724271 @default.
- W2357757910 hasConcept C168563851 @default.
- W2357757910 hasConcept C197934379 @default.
- W2357757910 hasConcept C204787440 @default.
- W2357757910 hasConcept C27081682 @default.
- W2357757910 hasConcept C2776000289 @default.
- W2357757910 hasConcept C2776468701 @default.
- W2357757910 hasConcept C2778375690 @default.
- W2357757910 hasConcept C42219234 @default.
- W2357757910 hasConcept C71924100 @default.
- W2357757910 hasConceptScore W2357757910C126322002 @default.
- W2357757910 hasConceptScore W2357757910C142724271 @default.
- W2357757910 hasConceptScore W2357757910C168563851 @default.
- W2357757910 hasConceptScore W2357757910C197934379 @default.
- W2357757910 hasConceptScore W2357757910C204787440 @default.
- W2357757910 hasConceptScore W2357757910C27081682 @default.
- W2357757910 hasConceptScore W2357757910C2776000289 @default.
- W2357757910 hasConceptScore W2357757910C2776468701 @default.
- W2357757910 hasConceptScore W2357757910C2778375690 @default.
- W2357757910 hasConceptScore W2357757910C42219234 @default.
- W2357757910 hasConceptScore W2357757910C71924100 @default.
- W2357757910 hasLocation W23577579101 @default.
- W2357757910 hasOpenAccess W2357757910 @default.
- W2357757910 hasPrimaryLocation W23577579101 @default.
- W2357757910 hasRelatedWork W1551373999 @default.
- W2357757910 hasRelatedWork W2010549507 @default.
- W2357757910 hasRelatedWork W2012369961 @default.
- W2357757910 hasRelatedWork W2016912337 @default.
- W2357757910 hasRelatedWork W2069134697 @default.
- W2357757910 hasRelatedWork W2079160239 @default.
- W2357757910 hasRelatedWork W2090188920 @default.
- W2357757910 hasRelatedWork W2162748306 @default.
- W2357757910 hasRelatedWork W2333654283 @default.
- W2357757910 hasRelatedWork W2352221759 @default.
- W2357757910 hasRelatedWork W2380892520 @default.
- W2357757910 hasRelatedWork W2411579787 @default.
- W2357757910 hasRelatedWork W2589648781 @default.
- W2357757910 hasRelatedWork W2914413686 @default.
- W2357757910 hasRelatedWork W2988342087 @default.
- W2357757910 hasRelatedWork W3012505939 @default.
- W2357757910 hasRelatedWork W3032875788 @default.
- W2357757910 hasRelatedWork W3095170134 @default.
- W2357757910 hasRelatedWork W3159562706 @default.
- W2357757910 hasRelatedWork W3029378183 @default.
- W2357757910 isParatext "false" @default.
- W2357757910 isRetracted "false" @default.
- W2357757910 magId "2357757910" @default.
- W2357757910 workType "article" @default.