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- W2357764773 abstract "Objective To investigate the protective effect of polysaccharide from Fructus Schisandrae on thymocyte apoptosis induced by cyclophosphamide(CY) in mice and to explore its possible mechanism.Methods Thymocyte apoptosis model was established in mice by intraperitoneal injection of CY.After treatment with different dosages of polysaccharide from Fructus Schisandrae,thymocyte apoptosis was detected by flow cytometry,TUNEL staining,and immunocytochemistry.Results CY-induced group had a higher apoptotic rate than the normal group,and the apoptotic rate was lower in polysaccharide group than that in the CY-induced model group(P 0.01).Expression of bcl-2 gene was inhibited,while expression of bax gene was promoted,and the Bcl-2/Bax ratio was decreased in CY-induced group.Polysaccharide from Fructus Schisandrae counteracted the above changes.Conclusion Polysaccharide from Fructus Schisandrae can inhibit the apoptosis of thymocytes induced by CY and relieve the damage of thymocytes,and its inhibitory mechanism may be related with promoting expression of bcl-2 gene and inhibiting protein expression of bax." @default.
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- W2357764773 date "2011-01-01" @default.
- W2357764773 modified "2023-09-23" @default.
- W2357764773 title "Protective Effect of Polysaccharide from Fructus Schisandrae on Cyclophosphamide-induced Thymocyte Apoptosis in Mice" @default.
- W2357764773 hasPublicationYear "2011" @default.
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