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- W2357766679 abstract "Objective To investigate the clinical application value of surface plasmon resonance(SPR) in detecting human papillomavirus subtype in patients with cervical lesions.Methods 109 patients who underwent screening for cervical lesions in Peking University People's Hospital and had not received any cervical treatment before were enrolled.Cytology was performed for everyone by liquid-based Thin-prep test.Colposcopy and biopsy were performed on patients who had a cytology result of ASCUS or greater.Testing for high-risk human papillomavirus(HPV) DNA were performed using HC2 method and HPV subtypes were detected using SPR method.These results were compared with the cloning and sequencing results.TERC gene expression were detected by FISH.Results (1) Regarding cloning and sequencing results as gold standard,the specificity of HPV-SPR in detecting high-risk HPV was significantly higher than HC2(P0.05),and there was no significant difference in sensitivity between them(P0.05).(2) In term of the pathology results,the sensitivity and NPV of SPR in identificating CIN 2 and above lesions were significantly lower than that of HC2 method in distinguishing the CIN 2 and above lesions(P0.05).There was no significant difference in specificity and PPV between the two methods(all P0.05).The specificity of TERC detecting in distinguishing the CIN 2 and above lesions was significantly higher than that of HC2 method(P0.01).There was no significant difference in sensitivity,PPV and NPV between this two methods(P0.05).Conclusions The specificity of SPR method in detecting high-risk HPV was higher than that of HC2 method.The sensitivity of the two methods in detecting high-risk HPV was comparative.Utilizing SPR method in high lesions can improve the specificity of liquid-based cytology and HC2 test and could avoid unnecessary colposcopy and treatment." @default.
- W2357766679 created "2016-06-24" @default.
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- W2357766679 date "2011-01-01" @default.
- W2357766679 modified "2023-09-24" @default.
- W2357766679 title "The clinical application of surface plasmon resonance in detection of human papillomavirus genotypes in patients with cervical lesions" @default.
- W2357766679 hasPublicationYear "2011" @default.
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