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- W2357773265 abstract "Objective To investigate the influence of Atracurium with different rate of intravenous injection on histamine release.Methods One hundred ASAⅠorⅡpatients were randomly divided into A, B, C and D groups with 25 cases in each. During the induction of anesthesia, the drug consumption of kg of midazolam, fentanyl and propofol and the rate of was the same for all patients. Atracurium 0.6mg/kg was injected in 5s for group A, in 10s for group B, in 20s for group C and in 30s for group D. The histamine concentration of plasma was detected before anesthesia induction and after 1min,3min,5min,7min,10min of atracurium was injected, MAP and HR were monitored and recorded at the same time.Results The histamine concentration of plasma in group A was significantly higher than that of other three groups(P0.05),and MAP increased and HR decreased significantly. The histamine concentration of plasma in group B and C gradually degraded when the rate of i.v of atracurium was step down. In group D it had no significant difference from that of before induction(P0.05).Conclusion The histamine release is significant positive correlation with rate of administration of atracurium. It can raise the safety of clinical medication when step down the rate of atracurium." @default.
- W2357773265 created "2016-06-24" @default.
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- W2357773265 date "2007-01-01" @default.
- W2357773265 modified "2023-09-24" @default.
- W2357773265 title "Effect of Atracurium with Different Rate of Intravenous Injection on Histamine Release" @default.
- W2357773265 hasPublicationYear "2007" @default.
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