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- W2357777229 abstract "The heparan sulfate(HS) mimetic PI-88 is a promising inhibitor of tumor growth and metastasis as an adjuvant therapy for postresection hepatocellular carcinoma.Its anti-neoplastic effect is mediated through the inhibition of tumor angiogenesis.It is also a potent inhibitor of heparanase,an enzyme that plays a key role in both tumor metastasis and angiogenesis.A series of PI-88 analogues have been synthesized,which can inhibit heparanase and bind to the angiogenic fibroblast growth factor 1(FGF-1),FGF-2,and vascular endothelial growth factor with similar affinity to PI-88.However,compared with PI-88,some of the newly designed compounds are more potent inhibitos of growth factor-induced endothelial cell proliferation and of endothelial tube formation on matrigel.Representative compounds were also tested for antiangiogenic activity in vivo and were found to reduce significantly blood vessel formation.Moreover,the pharmacokinetic profile of several analogues was also improved.The current data support the development of PI-88 mimetics as potent antiangiogenic anticancer agents." @default.
- W2357777229 created "2016-06-24" @default.
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- W2357777229 date "2008-01-01" @default.
- W2357777229 modified "2023-09-24" @default.
- W2357777229 title "Novel anticancer agents:PI-88 and its mimetics" @default.
- W2357777229 hasPublicationYear "2008" @default.
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