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- W2357778113 abstract "The bovine serum albumin poly(lactic acid) nanoparticles(NPs) were prepared by a double-emulsion solvent diffusion/evaporation method. Then the NPs were surface-modified with self-made water-soluble chitosan derivative(WSC) and polyvinyl alcohol(PVA), respectively. The particle size, ? potential, surface hydrophilicity and blood retention-time in mice of both NPs were investigated. The results showed that both NPs were in the size range of 100- 200 nm. Surface modifi cation with WSC could highly improve the surface hydrophilicity and adjust the surface charge close to neutrality(5.2 mV). The blood half-life of WSC-modifi ed nanoparticles calculated by DAS 2.0 software was 6.9 h, which was longer than that of PVA-modifi ed nanoparticles(0.3 h)." @default.
- W2357778113 created "2016-06-24" @default.
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- W2357778113 date "2014-01-01" @default.
- W2357778113 modified "2023-09-24" @default.
- W2357778113 title "Preparation and in vivo Long-circulating Property of Surface-modifi ed Polymeric Nanoparticles" @default.
- W2357778113 hasPublicationYear "2014" @default.
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