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- W2357782015 abstract "Objective To explore the relationship between leptin and insulin resistance in essential hypertension patients.Methods Homeostasis model assessment was applied to assess the status of insulin resistance(Homa IR).Serum leptin concentrations were determined in 49 healthy persons and 55 patients with essential hypertension by radioimmunoassay.The correlation between leptin and other parameters were analyzed.Results Serum leptin concentrations were significantly higher in females than in males (males:females=1:4).Serum leptin concentrations were a little higher in patients than in healthy persons (P0.05).Fasting serum insulin and Homa IR were significantly higher in patients than in healthy persons (P0.01 or P0.05).Peason analysis showed that fasting serum leptin concentrations were correlated with BMI (r=0.430,P0.01).After adjustment of sex and BMI,partial correlation analysis showed that serum leptin concentrations were not correlated with fasting serum true insulin and Homa IR (r=0.034,0.056,P 0.05).Serum leptin concentrations were not correlated with other parameters.Conclusion Insulin resistance and hyperinsulinemia played a role in pathogenesis of essential hypertension,but the relationship between leptin and insulin resistance and the pathogenesis of essential hypertension was not explicit." @default.
- W2357782015 created "2016-06-24" @default.
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- W2357782015 date "2004-01-01" @default.
- W2357782015 modified "2023-09-22" @default.
- W2357782015 title "A Correlative Study between Leptin and Insulin-Resistance in Hypertensive Patients" @default.
- W2357782015 hasPublicationYear "2004" @default.
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