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- W2357788154 abstract "Objective:To investigate the effects of Triptolide (TP) and Dexamethasone(DM) on expression of Fas mRNA and apoptosis of eosinophils(Eos) in bronchalveolar lavage fluid(BALF) in asthmatic guinea pigs. Methods: The guinea pigs were stimulated with ovalbumin(OA), after 48 hours, hypodense Eos(HEos) and normodense Eos(NEos) were purified from BALF by gradients of percoll. The purified Eos were incubated with different concentration of TP (10 -7 to 10 -4mol/L) or DM (10 -10to 10 -5mol/L) in RPMI1640 medium for 24 hours , the mRNA of Fas in Eos was measured by hybridization, apoptosis was detected by TUNEL. Results: Under the culture condition of TP or DM administration in vitro, the percentage of apoptotic Eos and Fas mRNA expression were increased significantly in a dose-dependent manner (P0.05) . The expression of Fas mRNA was correlated with Eos apoptosis. Conclusion:TP and DM promote Eos apoptosis and expression of Fas in vitro. Fas might be one of the mechanisms that TP and DM promotes apoptosis of Eos." @default.
- W2357788154 created "2016-06-24" @default.
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- W2357788154 date "2005-01-01" @default.
- W2357788154 modified "2023-09-27" @default.
- W2357788154 title "Influence of Triptolide and Dexamethasone on expression of Fas mRNA and apoptosis of eosinophils in asthmatic guinea pigs" @default.
- W2357788154 hasPublicationYear "2005" @default.
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