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- W2357788612 abstract "Objective To explore the relationship between the changes of leukocyte rheological characteristics and expression of cell adhesion molecules and psoriasis, and the effect of polysacchride sulfate(PSS) on them. Methods By using the DXC 300A erythrocyte deformability apparatus, platelet and thrombus adhesion dual purpose apparatus and enzyme linked immunosorbent assay (ELISA) methods, the changes of leukocyte deformability (LD),leukocyte adhesion function(LAF),leukocyte CD 18 expression and serum soluble intercellular adhesion molecule 1 (sICAM 1) were measured in patients with psoriasis before and after treatment with PSS. Results The leukocyte filtration index(LFI) ,leukocyte adhesion rate(LAR), leukocyte CD 18 expression and sICAM 1 concentration were significantly higher in patients with psoriasis than those in controls(t=6.860-22.650, P0.01). LFI, LAR were positively correlated to leukocyte CD 18 expression and sICAM 1 concentration(r=0.716,0.625, 0.600 ,0.596, P0.001) and LFI was positively correlated to LAR (r=0.607, P0.001). The LFI, LAR, CD 18 expression and sICAM 1 concentration were significantly lower in the patients after treatment with PSS than those in the patients before treatment (t=17.362-56.601, P0.001). Conclusion The abnormalities of leukocyte rheological characteristics and cell adhesion molecules expression may participate in the occurance and development of psoriasis, and PSS may have the effects of improving the leukocyte rheological characteristics and restraining the expression of cell adhesion molecules.;[" @default.
- W2357788612 created "2016-06-24" @default.
- W2357788612 creator A5007984120 @default.
- W2357788612 date "2000-01-01" @default.
- W2357788612 modified "2023-09-27" @default.
- W2357788612 title "THE EFFECT OF POLYSACCHRIDE SULFATE ON THE LEUKOCYTE RHEOLOGICAL CHARACTERISTICS AND THE EXPRESSION OF CELL ADHESION MOLECULES IN PATIENTS WITH PSORIASIS" @default.
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