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- W2357804956 abstract "Objective To investigate changes of serum nitric oxide (NO) after pancreaticoduo- denal transplantation and their significance.Methods Sun Lee's methods were employed to establish model of panereaticoduodenal transplantation in rats.All the recipients were divided into isograft group (Wistar-Wistrar,group A) and allograft group (SD-Wistar,group B).The grafted pancreas and blood were harvested on postoperative days 3,5,7 and 10 (POD 3,5,7 and 10).All samples were subjected to histopathological examination and the level of serum NO determined by nitric acid re- ductase method.Results In group A,no significant changes were seen in the grafted pancreas and level of serum NO.In group B,the pathological injury of the grafted pancreas was significantly aggra- vated and level of serum NO markedly increased along with increase in survival time after the operation (P0.05).The value of serum NO was 27.53+3.06,64.24+6.58,137.02+16.98 and 131.30+ 13.19 on POD 3,5,7 and 10,respectively.Meanwhile,it reached its peak on POD 7.On POD 10, the level slightly decreased.However,it was not significantly different from that on POD 7 (P 0.05).Conclusions The level of serum NO increasesd at the early stage of pancreaticoduodenal al- lograft rejection in rats.In addition,it might be used as an early diagnostic marker to detect acute al- lograft rejection." @default.
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- W2357804956 date "2001-01-01" @default.
- W2357804956 modified "2023-09-26" @default.
- W2357804956 title "Changes of serum nitric oxide after pancreaticoduodenal transplantation in rats" @default.
- W2357804956 hasPublicationYear "2001" @default.
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