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- W2357810273 abstract "Objective: To investigate the effect of lamotrigine(LTG) on learning and memory and the content of NMDA receptor activity in hippocampus of pentylenetetrazol(PTZ)-induced epileptic rats.Methods: Eighty healthy male SD rats,sixteen were assigned randomly control group,sixty four status epilepticus rats were randomly and equally divided into model group,low-dose group,middle-dose group and high-dose group,LTG were intraperitoneally injected every day for two weeks.The ability of learning and memory was tested by Morris water maze and Y maze.The expression of NMDA receptor in hippocampus was determined by immunohistochemical staining.Results: Learning and memory dysfunction was observed in epileptic rats,relative absorbance of NMDA receptor decreased significantly;model group rats treated with low-dose LTG showed no difference in learning and memory function compared with epileptic rats without LTG treatment,relative absorbance of NMDA receptor had no difference;middle and high-dose LTG appeared to improve the learning and memory function of epileptic rats,relative absorbance of NMDA receptor increased significantly.Conclusion: Status epilepticus can result in damages of learning and memory in immature rats,middle and high-dose LTG appears to improve the learning and memory function of epileptic rats,which might be relevant to its regulating effect on the expression of NMDA receptor in hippocampus." @default.
- W2357810273 created "2016-06-24" @default.
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- W2357810273 date "2011-01-01" @default.
- W2357810273 modified "2023-09-27" @default.
- W2357810273 title "Effect of lamotrigine on cognition and hippocampal NMDA receptor expression in developmental status epilepticus rats" @default.
- W2357810273 hasPublicationYear "2011" @default.
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