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- W2357840229 abstract "Objective To investigate the effects of propofol on the polymorphonuclear leukocytes(PMNs) in the lung ischemia-reperfusion(I/R) in rats.Methods A rat model of pulmonary warm I/R injury was established by clampping of the left lung hilus for 45min and then reperfusion for 2h.All rats were divided into 3 groups:sham (without clampping),I/R and propofol groups (I/R with propofol anesthesia).We measured the CD18 expression and respiratory burst (RB) of PMNs by flow cytometry,the compliance and wet to dry (W/D) weight ratio of the left lung,the levels of MDA and SOD in plasma.Results In pulmonary I/R injury,propofol at anesthetic dose inhibited CD18 expression and RB of PMNs,increased the compliance and decrease W/D of the left lung,reduced MDA levels,preserved SOD activity.Conclusion Propofol at anesthetic dose inhibit the activity of neutrophils and have protective effects on the pulmonary I/R injury in rats." @default.
- W2357840229 created "2016-06-24" @default.
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- W2357840229 date "2005-01-01" @default.
- W2357840229 modified "2023-09-23" @default.
- W2357840229 title "Effects of propofol on polymorphonuclear leukocytes in lung ischemia-reperfusion in rats" @default.
- W2357840229 hasPublicationYear "2005" @default.
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