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- W2357842637 abstract "Objective To evaluate the correlation between the changes of hippocampal volume and MMSE score in elder patients with mild cognitive impairment.Methods Sixteen senile patients and 14 controls were evaluated with the MMSE,global deterioration scale and Hachinski ischemic score.Screening of mild cognitive impairment patients was accomplished by the trained investigators in research team according to the grouping condition mentioned above.Three-dimensional measurement of hippocampal volume was performed by MRI tissue segmentation and volume measurement technology.Difference of hippocampal volume was compared by multivariable covariance analysis in order to exclude the influence of age and sexuality.Partial correlation analysis was used in study of relation between hippocampal volume and MMSE score.Results By controlling the effect of age and sex,the left side,right side and total hippocampal volume were smaller in the patients with mild cognitive impairment than those in controls(P0.05),and they were positive correlated with the change rate of MMSE score(r=0.812,P0.01;r=0.839,P0.01;r=0.852,P0.01).Conclusion MRI quantitative estimation of hippocampal atrophia can help the diagnosis of mild cognitive impairment.Hippocampal volume atrophia is an important influential factor of cognitive impairment in senile people." @default.
- W2357842637 created "2016-06-24" @default.
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- W2357842637 date "2009-01-01" @default.
- W2357842637 modified "2023-09-28" @default.
- W2357842637 title "Correlation study on MRI for mild cognitive impairment" @default.
- W2357842637 hasPublicationYear "2009" @default.
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