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- W2357851532 abstract "Objective:To establish an HPLC method for determination of content,uniformity and dissolution of Compound cefaclor capsules.Method:Waters shield RP C18 column(4.6 mm×250 mm,5μm)was used,the mobile phase was acetonitrile-0.025 mol/L potassium dihydrogen phosphate(adjusted to pH 3.0 with phosphoric acid)(22:78) at a folw rate of 1.0 mL/min,the column temperature was 30 ℃ and detection wavelength was 249 nm.Result:The good linearity for Cefaclor and Bromhexine hydrochloride of content,uniformity were 280.97-842.90 μg/mL(r=1.0000)and 11.00-33.01 μg/mL(r=1.0000); the average recoveries(n=3) for Cefaclor and Bromhexine of Compound cefaclor capsules were 99.8%,100.3% with RSD of 0.25%,0.86% and 101.2%,100.4% with RSD of 0.47%,0.98%; the good linearity for Cefaclor and Bromhexine hydrochloride of dissolution were 141.71-472.38 μg/mL(r=0.9991)and 4.83-14.531 μg/mL(r=0.9991);the average recoveries(n=3) for Cefaclor and Bromhexine hydrochloride of Compound cefaclor capsules were 99.6%,100.2% with RSD of 0.22%,0.64% and 100.8%,99.9% with RSD of 0.72%,0.47%.The content uniformities for Cefaclor and Bromhexine of compound cefaclor capsules were good,the drug dissolution at 30 min,cefaclor was above 80% and bromhexine was above 70%.Conclusion:Establishment of HPLC method has strong specificity,high sensitirity,simple operation and other characteristics,and at the same time study the content,uniformity and dissolution of Cefaclor and Bromhexine,can further control the drug quality." @default.
- W2357851532 created "2016-06-24" @default.
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- W2357851532 date "2014-01-01" @default.
- W2357851532 modified "2023-09-23" @default.
- W2357851532 title "The Research of Determination of Content,Uniformity and Dissolution of Compound Cefaclor Capsules by HPLC" @default.
- W2357851532 hasPublicationYear "2014" @default.
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