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- W2357859060 abstract "Objective To observe the effect of doxazosin(DOX)on blood lipid levels in rats with atherosclerosis.Methods New Zealand male rabbits were randomly divided into 3 groups:normal diet group,high fat diet group,DOX treatment group,with 10 rabbits in each group.The rabbits in normal diet group were fed with normal feed,however,the rabbits in the latter two groups were fed with high fat diet.After 4-week feeding,the rabbits in DOX treatment group were intraperitoneally injected with DOX 1mg/kg,once a day for 9 weeks.The serum levels of TC,TG,LDL-C were detected at 0,4,7,10,13 weeks for the three groups.Results The levels of TC in high fat diet group were(28.63±7.65)mmol/L at the end of 4 weeks,(40.83±3.90)mmol/L at the end of 13 weeks,and the levels of LDL-C were(16.21±9.59)mmol/L at the end of 4 weeks,(28.46±3.81)mmol/L at the end of 13 weeks respectively,with the time prolongation of high fat diet feeding,the levels of TC,LDL-C were increased further(P0.05 or0.01).However the levels of TC in DOX treatment group were(29.36±7.94) mmol/L at the end of 4 weeks,(37.59±6.09)mmol/L at the 13 weeks,and the levels of LDL-C were(17.66± 8.84)mmol/L at the end of 4 weeks,(25.50±6.70)mmol/L at the end of 13 weeks,the levels of TC,LDL-C were not increased significantly(P0.05).Conclusion DOX can improve the disorder of LDL-C and TC mildly in the rabbits with hyperlipemia." @default.
- W2357859060 created "2016-06-24" @default.
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- W2357859060 date "2012-01-01" @default.
- W2357859060 modified "2023-09-23" @default.
- W2357859060 title "Effects of doxazosin on blood lipid levels in cholesterol-fed rabbits models" @default.
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