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- W2357862210 abstract "Objective The failure of current treatments for conlon cancer has recently been attributed to the existence of cancer stem cells(CSC),which are difficult to be killed by drugs because of their chemoresistant properties as well as their ability to stimulate neoangiogenesis.The aim of the current study was to evaluate the antitumor efficacy of arsenic trioxide in vitro.The effect of arsenic trioxide(As2O3) on the expression of OCT4(Octamer binding proteins) and FOXO3a in colorectal cancer SW620 cells was investigated by FOXO3a gene silencing and exciting.Methods Human colorectal cancer SW620 cells were transfected with FOXO3a specific siRNA using liposome method and treated by PI3K inhibitor LY294002.The mRNA and protein expressions of OCT4 and FOXO3a in human colorectal cancer SW620 cells were detected respectively by reverse transcription-polymerase chain reaction(RT-PCR) and Western blot.Results ①The mRNA and protein expressions of FOXO3a were increased in human colorectal cancer SW620 cells treated by As2O3,while the expressions of OCT4 mRNA and protein were decreased(P 0.05).②The mRNA and protein expressions of FOXO3a were obviously decreased after transfection of FOXO3a specific siRNA,whereas the OCT4 mRNA and protein expressions were increased(P 0.05).The FOXO3a expressions of LY294002 treatment,however,were exactly contrary to that of siRNA.③When transfected with FOXO3a specific siRNA,As2O3 made no effect on the mRNA and protein expressions of OCT4(P 0.05).While treated by LY294002,As2O3 decreased the OCT4 mRNA and protein expressions(P 0.05).Conclusion As2O3 could decrease the expression of OCT4 in colorectal cancer SW620 cell and the underline mechanism may be associated with the upregulation of FOXO3a expression." @default.
- W2357862210 created "2016-06-24" @default.
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- W2357862210 date "2013-01-01" @default.
- W2357862210 modified "2023-09-22" @default.
- W2357862210 title "Effect of arsenic trioxide on the expression of OCT4 and FOXO3a in colorectal cancer SW620 cells" @default.
- W2357862210 hasPublicationYear "2013" @default.
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