Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357865540> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2357865540 abstract "Objective:To investigate the application of HLA-identical sibling allogeneic peripheral blood stem cell transplantation (allo-PBSCT) in the treatment of acute leukemia.Method:Between January 1997 and February 2004, fifty-two patients with acute leukemia (male 33, female 19, median age 33 years, range 13~54 years) received HLA-identical sibling allo-PBSCT with conditioning regimens of TBI-based regimen or chemotherapy-based regimen. Twenty-two patients were acute lymphoblastic leukemia, 28 with acute nonlymphoblastic leukemia. Sixteen cases were high-risk leukemia, 36 with standard-risk leukemia. Combination of cyclosporine and short-term methotrexate or tacrolimus (FK506) was administrated for GVHD prophylaxis while two patients with second allo-SCT received no immunosuppressive therapy. Forty-six patients received granulocyte colony-stimulating factor postallograft till neutrophil count above at least 0.5×109/L.Result:Engraftment occurred in all patients. The median time to ANC≥ 0.5×109/L and platelets ≥20×109/L were 11 and 17 days, respectively. Patients given G-CSF postallograft had significantly accelerated neutrophil Grade II~IV acute GVHD developed in 12 patients. Chronic GVHD was diagnosed in 60.9% evaluable patients with 43.5% limited cGVHD and 17.4% extensive GVHD. Low relapse rate ( 18.5% to 47.4%) and high five-year disease-free-survival (DFS)( 58.7± 9.7% to 33.3± 11.1% ) were observed in patients with cGVHD(P 0.05). Transplantation-related mortality (TRM) occurred in 11.5% patients within 100 days and 23.9% after 100 days. Five-year DFS was 39.7± 6.9%. Multivariate analysis showed the significant factors associated high DFS were continuous remission duration before transplantation and the occurrence of cGVHD while ABO-incompatible transplantation was with low DFS (P 0.05).Conclusion:allo-PBSCT resulted in rapid engraftment and increased cGVHD incidence. Continuous remission duration before transplantation and the occurrence of cGVHD were the significant factors associated high DFS while ABO-incompatible transplantation was with low DFS." @default.
- W2357865540 created "2016-06-24" @default.
- W2357865540 creator A5076994539 @default.
- W2357865540 date "2005-01-01" @default.
- W2357865540 modified "2023-09-23" @default.
- W2357865540 title "HLA-identical sibling allogeneic peripheral blood stem cell transplantation in the treatment of acute leukemia" @default.
- W2357865540 hasPublicationYear "2005" @default.
- W2357865540 type Work @default.
- W2357865540 sameAs 2357865540 @default.
- W2357865540 citedByCount "0" @default.
- W2357865540 crossrefType "journal-article" @default.
- W2357865540 hasAuthorship W2357865540A5076994539 @default.
- W2357865540 hasConcept C126322002 @default.
- W2357865540 hasConcept C138496976 @default.
- W2357865540 hasConcept C141071460 @default.
- W2357865540 hasConcept C15744967 @default.
- W2357865540 hasConcept C203014093 @default.
- W2357865540 hasConcept C2776194465 @default.
- W2357865540 hasConcept C2776694085 @default.
- W2357865540 hasConcept C2776863199 @default.
- W2357865540 hasConcept C2777767877 @default.
- W2357865540 hasConcept C2778461978 @default.
- W2357865540 hasConcept C2781059491 @default.
- W2357865540 hasConcept C2781413609 @default.
- W2357865540 hasConcept C2909675724 @default.
- W2357865540 hasConcept C2911091166 @default.
- W2357865540 hasConcept C71924100 @default.
- W2357865540 hasConcept C90924648 @default.
- W2357865540 hasConceptScore W2357865540C126322002 @default.
- W2357865540 hasConceptScore W2357865540C138496976 @default.
- W2357865540 hasConceptScore W2357865540C141071460 @default.
- W2357865540 hasConceptScore W2357865540C15744967 @default.
- W2357865540 hasConceptScore W2357865540C203014093 @default.
- W2357865540 hasConceptScore W2357865540C2776194465 @default.
- W2357865540 hasConceptScore W2357865540C2776694085 @default.
- W2357865540 hasConceptScore W2357865540C2776863199 @default.
- W2357865540 hasConceptScore W2357865540C2777767877 @default.
- W2357865540 hasConceptScore W2357865540C2778461978 @default.
- W2357865540 hasConceptScore W2357865540C2781059491 @default.
- W2357865540 hasConceptScore W2357865540C2781413609 @default.
- W2357865540 hasConceptScore W2357865540C2909675724 @default.
- W2357865540 hasConceptScore W2357865540C2911091166 @default.
- W2357865540 hasConceptScore W2357865540C71924100 @default.
- W2357865540 hasConceptScore W2357865540C90924648 @default.
- W2357865540 hasOpenAccess W2357865540 @default.
- W2357865540 hasRelatedWork W1970070684 @default.
- W2357865540 hasRelatedWork W2060741445 @default.
- W2357865540 hasRelatedWork W2291093094 @default.
- W2357865540 hasRelatedWork W2348815391 @default.
- W2357865540 hasRelatedWork W2358544521 @default.
- W2357865540 hasRelatedWork W2369520970 @default.
- W2357865540 hasRelatedWork W2373980086 @default.
- W2357865540 hasRelatedWork W2392601349 @default.
- W2357865540 hasRelatedWork W2416088548 @default.
- W2357865540 hasRelatedWork W2423160877 @default.
- W2357865540 hasRelatedWork W2462592994 @default.
- W2357865540 hasRelatedWork W2462778036 @default.
- W2357865540 hasRelatedWork W2479448821 @default.
- W2357865540 hasRelatedWork W2551552292 @default.
- W2357865540 hasRelatedWork W2554248392 @default.
- W2357865540 hasRelatedWork W2557361539 @default.
- W2357865540 hasRelatedWork W2992959047 @default.
- W2357865540 hasRelatedWork W3031580861 @default.
- W2357865540 hasRelatedWork W3150379508 @default.
- W2357865540 hasRelatedWork W808873125 @default.
- W2357865540 isParatext "false" @default.
- W2357865540 isRetracted "false" @default.
- W2357865540 magId "2357865540" @default.
- W2357865540 workType "article" @default.