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- W2357868109 abstract "AIM: To investigate the significance of human telomerase reverse transcriptase (hTERT) gene and c Myc protein in esophageal cancer and esophageal precarcinoma and to analyze the relationship between hTERT and c Myc protein. METHODS: Tissues of 42 esophageal carcinoma cases, 37 dysplasia cases and 12 normal esophageal cases were examined. The expression of hTERTmRNA and c Myc protein were determined by in situ hybridization and immunohistochemistry. RESULTS: In normal mucosa, dysplasia and neoplasms, the positive rates of hTERTmRNA were respectively 0,48.6%, 83.3% and c Myc were 0, 45.9%, 59.5%. The expression of hTERTmRNA and c Myc was significantly increased in neoplasms and dysplasia, compared with that in normal mucosa ( P0.01, P= 0.002, P0.01, P =0.004). The hTERTmRNA expression was significantly increased in neoplasms, compared with that in dysplasia( P =0.002). The expression of hTERTmRNA was significantly increased in the lymph nodepositive group ( P =0.01) and advanced carcinoma ( P =0.044). But c Myc protein was higher only in the lymph nodepositive group ( P =0.026) and had no statistic relation with other clinical and pathologic factors. The results also show that there was significant relation between the expression of hTERTmRNA and that of c Myc ( P 0.01). CONCLUSION: hTERTmRNA and c Myc overexpression may play an important role in the carcinogenesis and progression of esophageal cancer and the hTERTmRNA expression is related to c Myc protein." @default.
- W2357868109 created "2016-06-24" @default.
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- W2357868109 date "2003-01-01" @default.
- W2357868109 modified "2023-09-24" @default.
- W2357868109 title "Expression of human telomerase reverse transcriptase gene and c-Myc protein in esophageal cancer tissue" @default.
- W2357868109 hasPublicationYear "2003" @default.
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