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- W2357883988 abstract "OBJECTIVE:To investigate the change in BBB permeability and ultrastructure of microvessle in C6 glioma and the tight junction protein expression of Claudin-5,after whole-brain irradiated with the single dose.METHODS: Fifty tumor-bearing rats were randomly divided into sham irradiation group,5 Gy,10 Gy,15 Gy and 20 Gy group.All groups were 10 rats sacrificed at 24 h after irradiation,5 rats were using transmission electron microscopy of exogenous lanthanum nitrate(La3+)-tracing to observe the BBB permeability of he tissues within 2 mm to the border of the tumor and using immunohistochemical method to detect the expression of Claudin-5,repectively.RESULTS: Using TEM of exogenous La3+-tracing to observe the BBB permeability.In BAT of 5 Gy group,La3+ exuded to the local BM,most of which lied in endovascular.In BAT of 10 Gy group,La3+ exuded to a wide range of BM and the brain tissue space,and tight junctions were opened.In BAT of 15 Gy and 20 Gy group,La3+ seeped to the BM,extra-vascular,the space inside the brain tissue and cells.Statistical analysis showed that 20 Gy and 15 Gy 10 Gy 5 Gy and 0 Gy(P0.05).The expression of Claudin-5 in BAT of the tumor-bearing rats after irradiation with different doses was following up.Claudin-5 expression in BAT of 5 Gy Group was decreased than that in the control group brain tissue,showing moderate expression.Ten Gy group BAT Department could be seen moderate expression,combining with vascular distortion,deformation and continuous expression state.Fifty Gy,20 Gy group could be seen mild expression in BAT,showing intermittent and debris-like expression along the vessels.Statistical analysis showed that 20 Gy and 15 Gy 10 Gy 5 Gy and 0 Gy(P0.05).CONCLUSION: With dose changes during whole-brain radiotherapy,BBB begin opening from 15 Gy to 20 Gy,and significantly after single irradiation 15 Gy,20 Gy,in which the two doses have not differences." @default.
- W2357883988 created "2016-06-24" @default.
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- W2357883988 date "2011-01-01" @default.
- W2357883988 modified "2023-09-23" @default.
- W2357883988 title "Effect of whole-brain irradiated with the different doses on study of the tight junction of blood-brain barrier in glioma models" @default.
- W2357883988 hasPublicationYear "2011" @default.
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