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- W2357889916 abstract "Objective To investigate the effect of Qunine on expression of connexin 36(Cx36) in hippocampal neurons in epileptic rats.Methods Sixty-four SD rats were randomly divided into normal control group,epileptic model group,Diazepam therapy group and Qunine therapy group,and 16 rats in each group.Epileptic rat models were made by lithium chloride-pilocarpine method.Diazepam therapy group were given 1 mg/kg Diazepam by introperitoneal injection,and Qunine therapy group were given 60 mg/kg Qunine by introperitoneal injection.The Racine score and electroencephalography were used to decide epileptic seizure after operation respectively.The expression of Cx36 in hippocampal neurons in each group at 2 h and 4 h after operation was detected by immunofluorescent staining method and Western blot method respectively.Results Compared with normal control group,the expression of Cx36 in hippocampal neurons at 2 h and 4 h after operation were obviously increased in epileptic model group and Diazepam therapy group(all P0.01).There was no significant difference of the expression of Cx36 in hippocampal neurons at 2 h and 4 h after operation between epileptic model group and Diazepam therapy group.Compared with epileptic model group and Diazepam therapy group,the expression of Cx36 in hippocampal neurons at 2 h and 4 h after operation were obviously decreased in Qunine therapy group(all P0.01).Conclusions The expression of Cx36 in hippocampal neurons may increased in epilepsy rats.In addition,Qunine can suppress this change." @default.
- W2357889916 created "2016-06-24" @default.
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- W2357889916 date "2011-01-01" @default.
- W2357889916 modified "2023-09-23" @default.
- W2357889916 title "Effect of Qunine on expression of connexin 36 in hippocampal neurons in epileptic rats" @default.
- W2357889916 hasPublicationYear "2011" @default.
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